After reading an article in PC Mag I started using Avast, it's free. Automatically updates. Seems to be working great for about a year, I use Spybot to remove adware.
I've been using Avast for the last few months, along with Spybot. Unfortunately my computer still managed to get majorly f-ed up. I thought it was a virus that Avast missed at first so I went out and bought Norton, which didn't find anything either. Now I'm not really sure what's up...
So basically I don't have anything useful to add to the thread...